Analysis of BRCA1 Gene Character in Families with a History of BreastCancer

Abstract

Breast cancer is a type of cancer that is commonly found in women worldwide and ranks as the second leading cause of death among women after lung cancer. The aim of this study is to identify the inheritance of the BRCA1 gene in families with a history of breast cancer. This study used a descriptive correlational research design. The sample used consisted of families suspected of having a hereditary history of breast cancer, which was verified through interviews and pedigree analysis. The results showed that in Family 1, two individuals from the second generation experienced mutations at different points, specifically at positions del3280C and del2805A. Mutations were also found in a member of Family 2, where the individual experienced a mutation at position C2612T and had already been diagnosed with breast cancer. This occurred due to the inheritance of the mutation from the first generation (the mother) to her children.

Based on the analysis of the BRCA1 gene in 3 samples from